Searching for the Biology Behind Opioid Exposure.
Independent genetic and epigenetic research to better understand the long-term biological effects of opioids.
Research
Library
Engagement
Initiative
Could opioid exposure leave a measurable biological signature?
Understand
Clear explanations of the science.
Verify
Review evidence and regulatory records.
Participate
Help advance the research through DNA testing.
Real People.
Real Data.
A Healthier Tomorrow.
→
Why This Matters
Smith Genetic Research is investigating whether opioid exposure may be associated with measurable changes in human DNA, including epigenetic modifications such as DNA methylation, and whether these biological effects could help explain long-term health consequences in exposed individuals.
→ Explore the Science
Established Research
Published scientific findings
SGR Question
Independent research focus
Under Investigation
Needs further study
Explore Key Areas
Different perspectives. One connected mission.
Evidence at the Core
Transparency. Sources. Context.
Published Research
Peer-reviewed studies relevant to opioid biology, genes and epigenetics.
FDA & Regulatory
Citizen petitions, correspondence and public records.
SGR Analysis
Independent research and interpretation.
Research Talks
Hear Doug explain the research and key findings.
Following
the Evidence
A deeper examination of the biological questions surrounding opioid exposure.
Science begins with questions, evidence and the willingness to investigate.
The Opioid
Question
Exploring research, regulatory records and unanswered questions.
A search for greater understanding through science and evidence.
The Opioid Question
A Search for Answers
Dr. Douglas R. Smith takes you inside the science, the questions, and the human stories behind opioid exposure. This book explores the evidence, the unanswered questions, and the path toward a healthier tomorrow.
“A clear, thoughtful and evidence-based look at one of the most important health questions of our time.”
— Readers
Help Advance
the Research
Real progress comes when research questions can be studied through participant data. Your participation may help scientists better understand the biological effects of opioids.
Your Participation Journey
Learn
Understand the research
Register
Provide basic information
Receive Kit
Receive your DNA collection kit
Return Sample
Simple, non-invasive process
Support
Your data may contribute to scientific understanding
“Science advances when questions are asked, evidence is examined, and people come together to find answers.”
— Douglas R. Smith, MD
Founder, Smith Genetic Research
Built on Science.
Driven by Truth.
Independent
Research
Evidence-Based
Approach
Regulatory
Engagement
Laboratory-Grade
DNA Testing
Transparency in
Information
Participant Privacy
Focused
Latest Updates
Different perspectives. One connected mission.
Be Part of
the Research.
Explore the science. Review the evidence. Help advance understanding.
Start Your Participation →Explore Key Areas
Different perspectives. One connected mission
Research
Explore the science, key questions and what we're investigating.
Evidence Library
A searchable collection of studies, regulatory documents and more.
DNA Testing
Learn how testing works, who can participate and how your data helps.
FDA & Regulatory
Documents, petitions, responses and timelines.
About Doug
Physician, researcher, public advocate.
The Book
A deeper look at the questions that matter from Dr. Douglas R. Smith.
Data & Results
Find study updates, key findings and data visualizations.
Get Involved
Find study updates, key findings and data visualizations.
Published Research
Peer-reviewed studies relevant to opioid biology, genes and epigenetics.
FDA & Regulatory
Citizen petitions, correspondence and public records.
SGR Analysis
Independent research and interpretation.
Research Talks
Hear Doug explain the research and key findings.
THE BOOK
The Opioid Question
“A clear, thoughtful and evidence-based look at one of the most important health questions of our time.”
- Readers
Help Advance the Research
- Make a meaningful contribution to independent research
- Simple, non-invasive DNA sample collection
- Handled by a qualified laboratory
- Secure, confidential and privacy-focused
Help Advance the Research
Learn
Understand the research
Register
Provide basic information
Receive Kit
Provide basic information
Return Sample
Simple, non-invasive process
Support
Your data may contribute to scientific understanding
“Science advances when questions are asked, evidence is examined, and people come together to find answers.”
— Douglas R. Smith, MD
Founder, Smith Genetic Research
Built on Science. Driven by Truth.
Independent Research
Evidence-Based Approach
Regulatory Engagement
Laboratory-Grade DNA Testing
Transparency in Information